3. Luc Nilis – double leg fracture (2000) Recovery time: Never played again
In just his third game for Aston Villa, the highly-rated forward, who Ronaldo named as one of his greatest ever strike partners – suffered a career-ending double fracture after colliding with Richard Wright.
There was a rumour that Nilis would need an amputation after the injury became infected and, although that wasn’t the case, he was forced to hang up his boots shortly after.
4. Alf-Inge Haaland – horrific knee injury (2001) Recovery time: A few days (technically)
Arguably the most infamous injury to happen in the Premier League, and the only case in the list where the offender deliberately wanted to hurt the player, and who can it be except Roy Keane.
A famous act of revenge by a player, although Haaland played for Norway and Manchester City in the proceeding weeks. But the tackle was attributed for one of the reasons Haaland was forced to retire early in 2003 and it was even suggested that he would sue the Manchester United midfielder.