The San Francisco 49ers had a rather disappointing campaign in 2024. After finishing the previous three seasons winning 10+ games and making the playoffs in each season, they finished the 2025 season with a 6-11 overall record, placing last in the NFC West.
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Injuries, lack of play, and other factors led to the surprise down year, and this year’s team will look to bounce back from that. Joining Rich Eisen on his show, 49ers super fan and “Karate Kid: Legends” Actor Joshua Jackson went through a game-by-game prediction of whether he thinks the 49ers will win or lose against their opponent.
Jackson predicted the 49ers to go back to their winning ways, finishing the season with an 11-6 overall record and a hot 4-0 start. Here is Jackson’s game-by-game prediction for the 49ers this season:
Week 1 @ Seahawks: win
Week 2 @ Saints: win
Week 3 Home vs. Cardinals: win
Week 4 Home vs Jaguars: win
Week 5 @ Rams: Loss
Week 6 @ Buccaneers: Loss
Week 7 Home vs Falcons: Win
Week 8 @ Texans: Loss
Week 9 @ Giants: Win
Week 10 Home vs Rams: Win
Week 11 @ Cardinals: Loss
Week 12 Home vs Panthers: Win
Week 13 @ Browns: Loss
Week 14 BYE
Week 15 Home vs Titans: Win
Week 16 @ Colts: Win
Week 17 Home vs Bears: Loss
Week 18 Home vs Seahawks: Win
The San Francisco 49ers face an uphill battle if they hope to recapture the success of recent seasons. The NFC West is shaping up to be a gauntlet once again, with the Los Angeles Rams and Seattle Seahawks both finishing 10-7 last year, the Rams ultimately taking the division crown.
Seattle enters a new era with quarterback Sam Darnold, who orchestrated an unexpected playoff run with the Vikings last season. If he can carry some of that momentum into 2025, the Seahawks could be right back in the postseason hunt.
Meanwhile, the Rams continue to thrive under head coach Sean McVay. Though they’ve undergone roster changes, they remain a well-coached, resilient team with a championship pedigree—still just a few seasons removed from their Super Bowl triumph.
The Arizona Cardinals surprised many by finishing 8-9 and ahead of the 49ers in the standings. With a healthy Kyler Murray and the right supporting cast, the Cardinals are capable of explosive performances and could be a wildcard threat if everything clicks.
For the 49ers, everything hinges on quarterback Brock Purdy. Now one of the highest-paid signal-callers in the league after signing a five-year, $265 million deal, Purdy must step into an even larger leadership role, especially after the team lost key players like Deebo Samuel, Dre Greenlaw, Talanoa Hufanga, and Jordan Mason.
With so many changes, it won’t be easy for San Francisco to finish above .500. But if Purdy can recapture the magic he’s shown in the past, the 49ers might just have one more Cinderella run left in them.
